Graham Pawelec, MA, PhD

Consulting Scientist, Health Sciences North Research Institute
Professor, University of Tübingen
graham.pawelec@uni-tuebingen.dehttp://www.tati-group.de/

Graham Pawelec received an MA in Natural Sciences and a PhD in Transplantation Immunology from the University of Cambridge, UK. He is currently Professor of Experimental Immunology at the Center for Medical Research, Second Department of Internal Medicine, University of Tübingen Medical School, Tübingen, Germany. He is a Visiting Professor, Nottingham Trent University, UK and at King´s College London, holds an Honorary Chair at Manchester University, UK and acts as a “Cancer Solutions Consultant” at the Health Sciences North Research Insitute of Canada, Sudbury, ON. He is Co-Editor-in-Chief of “Cancer Immunology Immunotherapy” and Deputy Editor of the “Journal of Translational Medicine” and “Immunity and Aging”.

Selected Affiliations

Dr. Pawelec serves on several editorial boards including Editor-in-Chief of the Cancer Immunology Imunotherapy (Editorial Board member, 1998, Editor-in-Chief, 2003-present). He is the Deputy Editor of the BMC Immunity and Ageing (2004-present) and BMC J Translational Medicine (2008-present). Other Editorial Board Memberships include: Mechanisms of Ageing and Development (1996-present), Experimental Gerontology (1997-present) Nutrition and Aging (2011-present); Journals of Gerontology Series A (2013-present); Age (2015-present), and Biogerontology (1999-present). He holds memberships in the British Society for Immunology, Deutsche Gesellschaft für Gerontologie und Geriatrie, Deutsche Gesellschaft für Immunologie, European Association for Cancer Research, Association for Immunotherapy of Cancer, American Association for Cancer Research, British Asociation for Research on Ageing, American Association for Clinical Oncology, Society for the Immunotherapy of Cancer, American Association of Immunologists, Gerontological Society of America.

Research Interests

Research interests are currently centered on alterations to immunity, especially T cell-mediated immunity, in ageing and cancer in man, and the influence these have on the outcome of vaccination and immunomodulatory antibody therapies. The impact of polypathogenicity (including multiple infections, cancer, Alzheimer´s, diabetes, autoimmunity) as well as stress (psychological, nutritional) on immune signatures reflecting individual immune status is of particular interest in the clinical context. 

Current Funding

Dr. Pawelec’s research is supported by the German Research Foundation, the Fortüne Foundation, German Academic Exchange Program, German Federal Ministry for Education and Research, and the German Research Society.

Selected Publications

  • Wistuba-Hamprecht K, Martens A, Weide B, Teng KW, Zelba H, Guffart E, Chen J, Garbe C, Newell EW, Larbi A, Pawelec G. Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients. J Immunol. 2016 Dec 16. pii: 1600875. [Epub ahead of print]
  • Goldeck D, Larsen LA, Christiansen L, Christensen K, Hamprecht K, Pawelec G, Derhovanessian E.Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection. J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1537-1543.
  • Haq K, Fulop T, Tedder G, Gentleman B, Garneau H, Meneilly GS, Kleppinger A, Pawelec G, McElhaney JE. Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status. J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1163-1170. doi: 10.1093/gerona/glw216.
  • Bailur JK, Pawelec G, Hatse S, Brouwers B, Smeets A, Neven P, Laenen A, Wildiers H, Shipp C. Immune profiles of elderly breast cancer patients are altered by chemotherapy and relate to clinical frailty. Breast Cancer Res. 2017 Feb 28;19(1):20. doi: 10.1186/s13058-017-0813-x.
  • Wistuba-Hamprecht K, Martens A, Heubach F, Romano E, Geukes Foppen M, Yuan J, Postow M, Wong P, Mallardo D, Schilling B, Di Giacomo AM, Khammari A, Dreno B, Maio M, Schadendorf D, Ascierto PA, Wolchok JD, Blank CU, Garbe C, Pawelec G, Weide B. Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients. Eur J Cancer. 2017 Mar;73:61-70. doi: 10.1016/j.ejca.2016.12.011. Epub 2017 Feb 4.
  • Fortis SP, Sofopoulos M, Sotiriadou NN, Haritos C, Vaxevanis CK, Anastasopoulou EA, Janssen N, Arnogiannaki N, Ardavanis A, Pawelec G, Perez SA, Baxevanis CN. Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer. J Immunother Cancer. 2017 Apr 18;5(1):39. doi: 10.1186/s40425-017-0240-7.
  • Goldeck D, Theeten H, Hassouneh F, Oettinger L, Wistuba-Hamprecht K, Cools N, Tsitsilonis OE, Pawelec G. Frequencies of peripheral immune cells in older adults following seasonal influenza vaccination with an adjuvanted vaccine. Vaccine. 2017 Aug 3;35(34):4330-4338. doi: 10.1016/j.vaccine.2017.06.082. Epub 2017 Jul 6.
  • Le Page A, Lamoureux J, Bourgade K, Frost EH, Pawelec G, Witkowski JM, Larbi A, Dupuis G, Fülöp T. Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients. J Alzheimers Dis. 2017 Jul 29. doi: 10.3233/JAD-170124. [Epub ahead of print]
  • Le Page A, Garneau H, Dupuis G, Frost EH, Larbi A, Witkowski JM, Pawelec G, Fülöp T. Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients. Front Immunol. 2017 Jul 7;8:783. doi: 10.3389/fimmu.2017.00783. eCollection 2017

Honors and Awards

  • Visiting Professor, Nottingham Trent University, UK, 2005 – Present
  • Honorary Chair, Manchester University, 2010 – Present
  • Member of the Faculty of 1000 Oncology, 2012-Present
  • Fellow of the Gerontological Society of America (elected 2015)
  • Visiting Professor, King´s College, University of London, 2016 - Present